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Dual-acting agents for improving cognition and real-world function in Alzheimer’s disease: Focus on 5-HT6 and D3 receptors as hubs
Mark J. Millan, Anne Dekeyne, Alain Gobert, Mauricette Brocco, Clotilde Mannoury la Cour, Jean-Claude Ortuno, David Watson and Kevin C.F. Fone Neuropharmacology 177 108099 (2020) https://doi.org/10.1016/j.neuropharm.2020.108099
Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders
The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders
Targeting the dopamine D3 receptor: an overview of drug design strategies
Antoni Cortés, Estefanía Moreno, Mar Rodríguez-Ruiz, Enric I. Canela and Vicent Casadó Expert Opinion on Drug Discovery 11(7) 641 (2016) https://doi.org/10.1080/17460441.2016.1185413
The dopamine D 3 -preferring D 2 /D 3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia
Transient and rapid activation of Akt/GSK‐3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens
Marie‐Josèphe Salles, Denis Hervé, Jean‐Michel Rivet, Sophie Longueville, Mark J. Millan, Jean–Antoine Girault and Clotilde Mannoury la Cour Journal of Neurochemistry 125(4) 532 (2013) https://doi.org/10.1111/jnc.12206
Dopamine D3 receptor antagonism—still a therapeutic option for the treatment of schizophrenia
In Vivo Occupancy of Dopamine D3 Receptors by Antagonists Produces Neurochemical and Behavioral Effects of Potential Relevance to Attention-Deficit–Hyperactivity Disorder
V. Barth, A.B. Need, E.T. Tzavara, B. Giros, C. Overshiner, S.D. Gleason, M. Wade, A.M. Johansson, K. Perry, G.G. Nomikos and J.M. Witkin The Journal of Pharmacology and Experimental Therapeutics 344(2) 501 (2013) https://doi.org/10.1124/jpet.112.198895
Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: The CNTRICS initiative
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Mark J. Millan, Yves Agid, Martin Brüne, et al. Nature Reviews Drug Discovery 11(2) 141 (2012) https://doi.org/10.1038/nrd3628
Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents
S Miyamoto, N Miyake, L F Jarskog, W W Fleischhacker and J A Lieberman Molecular Psychiatry 17(12) 1206 (2012) https://doi.org/10.1038/mp.2012.47
Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment
David J. G. Watson, Charles A. Marsden, Mark J. Millan and Kevin C. F. Fone The International Journal of Neuropsychopharmacology 15(04) 471 (2012) https://doi.org/10.1017/S1461145711000435
Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice
Martin Egeland, Xiaoqun Zhang, Mark J. Millan, Elisabeth Mocaer and Per Svenningsson Journal of Neurochemistry 123(5) 811 (2012) https://doi.org/10.1111/jnc.12011
Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex
From the cell to the clinic: A comparative review of the partial D2/D3 receptor agonist and α2-adrenoceptor antagonist, piribedil, in the treatment of Parkinson's disease
The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures
Mark J. Millan, Jerry J. Buccafusco, Florence Loiseau, et al. The International Journal of Neuropsychopharmacology 13(08) 1035 (2010) https://doi.org/10.1017/S1461145710000775
Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D1 receptor agonists, but not of D2 antagonists
Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: Improvements of affinity and selectivity for D3 versus D2 receptors
Jean-Louis Peglion, Christophe Poitevin, Clotilde Mannoury La Cour, Delphine Dupuis and Mark J. Millan Bioorganic & Medicinal Chemistry Letters 19(8) 2133 (2009) https://doi.org/10.1016/j.bmcl.2009.03.015
Dual- and Triple-Acting Agents for Treating Core and Co-morbid Symptoms of Major Depression: Novel Concepts, New Drugs