Volume 70, Numéro 2, Mars-Avril 2015
Addictovigilance : le défi pharmacologique de l'évaluation et de la prévention des substances à risque
|Page(s)||157 - 165|
|Section||Addictovigilance / Addictovigilance|
|Publié en ligne||9 avril 2015|
Drug Abuse Monitoring: Which Pharmacoepidemiological Resources at the European Level?
CEIP-Addictovigilance de Toulouse, Service de
Pharmacologie Médicale et Clinique, CHU de Toulouse, Toulouse,
Inserm U1027, Université Paul Sabatier - Toulouse 3, Toulouse, France
Correspondence and offprints: Maryse Lapeyre-Mestre, Service de
Pharmacologie Médicale et Clinique, Faculte de Médecine, 37 Allées Jules Guesde, 31000
Toulouse France E-mail: email@example.com
Accepted: 9 October 2014
Monitoring the potential for abuse and dependence of psychoactive substances falls within the scope of international conventions on narcotic drugs. At the European level, this monitoring is based on activities controlled by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) for substance abuse in general and by the European Medicines Agency (EMA) for marketed drugs, in the context of pharmacovigilance. If France has set up in the early 1990s an original system to assess potential for abuse of psychoactive substances, with specific tools combining both the evaluation of the use of these substances (illicit substances or diverted drugs), and the consequences of that use in terms of morbidity and mortality, there is no equivalent in other European countries. Indeed, unlike the USA, who, for several decades, organized this type of surveillance, with a multisource approach (sentinel systems, databases, medical and administrative data, databases for seeking care in relation abuse), we have not found in other European countries integrated system for identifying a signal of drug abuse, or to assess the impact of measures for minimizing the risk of abuse. However, some recent examples show a growing concern about drug addiction, based on a pharmacoepidemiological approach using pharmacovigilance databases or medical administrative data. These examples illustrate the interest of these approaches in the field of drug of abuse.
Key words: pharmacology / pharmacoepidemiology / databases / misuse / abuse / dependence / drug abuse monitoring / psychotropic drugs / pregabalin
© 2015 Société Française de Pharmacologie et de Thérapeutique